Dosage- 500-1000mg/ Day
BCM-95® (CURCUGREEN®) for all round health benefits
BCM-95® (CURCUGREEN®) is a 100 percent pure extract of turmeric with enhanced bio-availability and bio-efficacy. Its powerful health-promoting benefits are derived from the colorful and aromatic qualities of the Indian spice.
In a pilot phytotherapy clinical study conducted in 2012, we evaluated the safety and effectiveness of curcumin alone, and in combination with an NSAID. The primary and secondary endpoints were reduction in (DAS) 28 Score and ACR score, assessments used by clinicians that measures various joint-related parameters. Subjects in all three treatment groups showed statistically significant changes in their DAS scores. Interestingly, the Curcumin group showed the highest percentage of improvement in overall DAS and ACR scores (ACR 20, 50 and 70) and these scores were significantly better than the subjects in the NSAID group. More importantly, curcumin treatment was found to be safe and did not relate with any adverse events.
In a double-blind, placebo-controlled, randomized study, subjects were randomized in 3 Groups each taking 4 grams of placebo, 1 gram of bioavailable Curcumin (BCM-95® (CURCUGREEN®)) and 4 grams of Conventional Curcumin Extract. At 0, 1 and 6 months plasma was taken to measure antioxidants and serum to monitor AB and liver and kidney functions. Over 1 month, Vitamin E levels in plasma were significantly increased in bioavailable Curcumin group compared to others. Moreover, subjects taking bioavailable Curcumin had greater levels of curcuminoids than the other. Serum beta-Amyloids tended to rise possibly reflecting an ability of Curcumin to disaggregate beta-Amyloids deposits in the brain, releasing them for circulation and disposal. There were no side effects reported in highly bioavailable Curcumin group, rather there were few adverse events on conventional Curcumin group.
A study evaluated hepatoprotective activity of combination of Phyllanthus niruri and Curcuma longa extracts (BCM-95® (CURCUGREEN®)) against CCl4 induced hepatotoxicity. Histological section of liver in animals treated with CCl4 showed centrilobular area of necrosis with derangement in hepatic architecture. PN+CL administration prevented these deleterious changes, histological section of liver in rats treated with PN+CL showed normal hepatic parenchyma. Combination of Phyllanthus niruri + Curcuma longa extracts showed significant hepatoprotection against CCl4 induced liver damage.
Some previous in vitro and in vivo studies have proposed a radio protective role for curcumin, the yellow pigment of turmeric. The purpose of this investigation was to assess the radio protective effects of curcumin supplementation in subjects undergoing external beam radiotherapy (EBRT). Quality of life was assessed by the quality of life questionnaire (QLQ-PR25). Analysis of covariance was used to compare radiotherapy related symptoms between groups following the intervention, adjusted for baseline symptoms. The change in urinary symptoms across the 20-week period differed significantly between groups (p=0.011) and subjects in the curcumin group experienced much milder urinary symptoms compared with the placebo group. No group differences were observed in any other domain of the QLQ-PR25. Curcumin can confer radio protective effect in through reducing the severity of radio therapy related urinary symptoms.
BCM-95® (CURCUGREEN®) is a major ingredient in BD. A study was to evaluate the effect of the dietary supplement BreastDefend (BD) on the proliferation and invasive behavior in MDA-MB-231 breast cells treated with BD (0-40 μg/mL) by MTT assay and trypan blue staining, respectively. Effect of BD on invasiveness was assessed by cellular adhesion, migration, and invasion assays. BD treatment suppressed the invasive behavior of MDA-MB-231 cells by the inhibition of cellular adhesion, migration, and invasion. This inhibition of invasiveness was mediated by the suppression of secretion of urokinase plasminogen activator (uPA), and by the down regulation of expression of CXCR4 in breast cancer cells treated with BD. Conclusion: BD inhibits proliferation and invasive behavior of MDA-MB-231 cells in vitro. BD may have a therapeutic potential for breast health support.
Mood and Stress Support
Curcumin is the active ingredient of commonly used spice Curcuma longa Linn. In a study, the mood-modulating activity of curcumin (BCM-95® (CURCUGREEN®)) and its combination with SSRIs was studied in various tests. The effect of curcumin (100 mg/kg) was similar to that of SSRIs (p > 0.05) but its addition to SSRIs did not improve their activity (p >0.05). It was concluded that its mood-modulating activity could be due to an increase in serotonin, norepinephrine and dopamine levels in the brain. Curcumin can be a useful mood-modulator especially in cases which respond to drugs having mixed effects on serotonin and catecholamines levels in the brain.
Several studies have demonstrated the healthy mood support effects of curcumin and saffron. In a randomised, double-blind, placebo-controlled study, 123 individuals were allocated to one of four treatment conditions. It was concluded that differing doses of curcumin and combined curcumin/saffron were effective in supporting healthy mood function.
Among obesity-associated disorders, low-grade inflammation has been described. A study confirmed that hesperidin and naringin or highly bioavailable curcumin extract have beneficial effects, targeted in the liver and could improve the obesity-related inflammatory state. In another study, anti-inflammatory activity of bio-enhanced turmeric formulation (BCM-95® (CURCUGREEN®)) was compared with commercial Curcumin formulation (Curcuminoids 95%) in Carrageenan-induced acute inflammatory model. In this study, all treatment groups demonstrated significant (p < 0.05) anti-inflammatory activity. The authors concluded that BCM-95® (CURCUGREEN®) treated groups showed significant healthy inflammatory response support compared to Curcuminoid 95% treated groups.
WHY SHOULD YOU CHOOSE
BCM-95® (CURCUGREEN®) ?
- Most researched bio available curcumin in the world
- Highest potency bioavailable turmeric extract
- Over 18 years of market leadership
- Safest bio available curcumin – 100% turmeric & 100% Natural
- Over 53 international patents
- Green Clean and traceable
- Available in over 60 countries in over 300 formulations
- Widest Range of Product variants
- Proven and studied mechanism of action